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Zika Virus - Recent updates 2016

Zika virus is a RNA virus belonging to filovirus family and transmitted by Aedes mosquitoes.
Its maternal-fetal transmission and anecdotal reports of sexual transmission have been reported.
Aedes mosquitoes usually bite during the daytime and breed in standing water so prevention is similar to dengue fever.
It’s a predominant mild or asymptomatic dengue like disease without any hemorrhagic tendencies. Symptoms occur in just 20-25% of patients with low case fatality rates. . It causes acute onset low grade fever with multiple small joint pain, muscle ache, eye pain, prostration and maculopapular rash and usually present 2 to 12 days after mosquito bite.
Recent reports suggests its association with fetal microcephaly and intra cranial calcification which requires antenatal serial Ultrasonography and biochemical evaluation in suspected cases
Treatment is bed rest and supportive care.

Similar to dengue aspirin should be avoided and hematocrit and pulse pressure needs to be monitored.
Diagnostic Algorithm for Zika virus detection
Reference :- PAHO & WHO guidelines

Dengue fever - What you must know



It’s a viral infection caused by flavivirus and transmitted by aedes mosquito.

Aedes mosquito usually bites during day time and breeds in stagnant water. Since dengue virus has four antigens so there is risk of getting dengue again for maximum 4 times.

Usually it’s a self limiting illness but it may progress to Dengue hemorrhagic fever and Dengue shock syndrome.

Thrombocytopenia is usually seen on 3-4 day of fever and decreasing trend till 6th day and again increases from 7th day.

If there is pain abdomen, breathlessness, bleeding, hypotension or low blood pressure, hospitalization is recommended.

Rule of 20 for Doctors - Rise in hematocrit (pcv) more than 20% and fall by 20% after fluid replenishment, 20 petechiae in tourniquet test, pulse pressure less than 20mm of hg

Treatment remains supportive... paracetamol for fever and plenty of fluids. For inpatients if platelet is less than 10000 platelet transfusion is done. Avoid drugs which may cause thrombocytopenia...


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Diabetes management during Ramadan




Ramadan, a holy month of Islam varies between 29 and 30 days. Muslims who fast abstain from eating drinking smoking and use of oral medications.
Patients of diabetes mellitus who fast are at greater risk of complications which are hypoglycemia (low blood sugar), hyperglycemia (high blood sugar), Diabetic ketoacidosis, dehydration and thrombosis.
Medical recommendation most often for the patients is to not undertake fasting. But if they insist on fasting they must make such decision in consultation with their doctors understanding risks associated with it.
Management is individual centric.
General considerations
1. There should be frequent monitoring of blood glucose level.
2. Nutrition should be adequate enough to maintain a constant body mass. Avoid taking heavy sunset meals rich in carbohydrate and fats. Take plenty of fluids during non fasting hours and food containing complex carbohydrates at the predawn meal is advised.
3. Normal level of exercise. Avoid excessive exercise as it may cause hypoglycemia.
4. Breaking the fast. If blood sugar is less than 60mg/dl anytime or less than 70mg/dl within few hours of fast, or if blood sugar is in excess of 300mg/dl.



Management of Type 2 Diabetes mellitus


1. Patients controlled with lifestyle modification alone may distribute calories over 2 to 3 smaller meals to avoid hyperglycemia.
2. Patients on oral drugs- insulin sensitizers like metformin are preferred.
Those treated with metformin can safely fast. Dose needs to be modified - 2/3 of total dose should be given with sunset meal and 1/3 before predawn meal.
Pioglitazones are not independently associated with hypoglycemia but they can’t be substituted for any other OHA as it takes 2-4 weeks to exert its effects.
Sulfonylureas like glimepride, glyburide, glipizide are not recommended in view of hypoglycemia risk.
Glinides may be taken twice daily as it is short acting.
DPP 4 inhibitors (gliptins) are best tolerated drugs and can be taken. Alpha glucosidase inhibitors like acarbose miglitol and voglibose can be taken.



Patients treated with insulins :


One long or intermediate acting insulin injection along with short acting insulin before meal can be used. Use of 50:50 premixed insulin in evening and 30:70 insulin at early morning was also found useful.
Insulin pump is better option.



References :- ADA guidelines

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Snake bite - what should not be done

What should not be done?

1. Do not apply a tourniquet. (Don’t tie arm or leg with rope or clothes as it’s unnecessary and makes the condition worse for the patient.)
2. Do not wash the bite site with soap or any other solution to remove the venom. 
3. Do not make cuts or incisions on or near the bitten area.
4. Do not use electrical shock.
5. Do not freeze or apply extreme cold to the area of bite. 
6. Do not apply any kind of potentially harmful herbal or folk remedy.
7. Do not attempt to suck out venom with your mouth.
8. Do not give the victim drink, alcohol.
9. Do not attempt to capture, handle or kill the snake and 
9. Patients should not be taken to quacks.

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IQ Classifications




IQ score ranges (from DSM-IV): 

  • Mild mental retardation: IQ 50–55 to 70; children require mild support; formally called "Educable Mentally Retarded".

  • Moderate retardation: IQ 35–40 to 50–55; children require moderate supervision and assistance; formally called "Trainable Mentally Retarded".

  • Severe mental retardation: IQ 20–25 to 35–40; can be taught basic life skills and simple tasks with supervision.

  • Profound mental retardation: IQ below 20–25; usually caused by a neurological condition; require constant care.
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    National Health Committees


    Various committees of experts have been appointed by the government from time to time to render advice about different health problems. The reports of these committees have formed an important basis of health planning in India. The goal of National Health Planning in India is to attain Health for all by the year 2000.
    1. BHORE COMMITTEE. 1946.
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    This committee, known as the Health Survey & Development Committee, was appointed in 1943 with Sir Joseph Bhore as its Chairman. It laid emphasis on integration
    of curative and preventive medicine at all levels. It made comprehensive recommendations for remodeling of health services in India. The report, submitted in 1946, had
    some important recommendations like :-

    1.Integration of preventive and curative services of all administrative levels.

    2. Development of Primary Health Centres in 2 stages :
    a. Short-term measure – one primary health centre as suggested for a population of 40,000. Each PHC was to be manned by 2 doctors, one nurse, four public health
    nurses, four midwives, four trained dais, two sanitary inspectors, two health assistants, one pharmacist and fifteen other class IV employees. Secondary health centre
    was also envisaged to provide support to PHC, and to coordinate and supervise their functioning.

    b. A long-term programme (also called the 3 million plan) of setting up primary health units with 75 – bedded hospitals for each 10,000 to 20,000 population and
    secondary units with 650 – bedded hospital, again regionalised around district hospitals with 2500 beds.

    3. Major changes in medical education which includes 3 - month training in preventive and social medicine to prepare “social physicians”.
    2. MUDALIAR COMMITTEE. 1962.
    This committee known as the “Health Survey and Planning Committee”, headed by Dr. A.L. Mudaliar, was appointed to assess the performance in health sector since
    the submission of Bhore Committee report. This committee found the conditions in PHCs to be unsatisfactory and suggested that the PHC, already established
    should be strengthened before new ones are opened.

    Strengthening of sub divisional and district hospitals was also advised. It was emphasised that a PHC should not be made to cater to more than 40,000 population and
    that the curative, preventive and promotive services should be all provided at the PHC. The Mudaliar Committee also recommended that an All India Health service should
    be created to replace the erstwhile Indian Medical service.

    3. CHADHA COMMITTEE, 1963.
    This committee was appointed under chairmanship of Dr. M.S. Chadha, the then Director General of Health Services, to advise about the necessary arrangements for
    the maintenance phase of National Malaria Eradication Programme. The committee suggested that the vigilance activity in the NMEP should be carried out by basic
    health workers (one per 10,000 population), who would function as multipurpose workers and would perform, in addition to malaria work, the duties of family planning
    and vital statistics data collection under supervision of family planning health assistants.
    4. MUKHERJEE COMMITTEE. 1965.
    The recommendations of the Chadha Committee, when implemented, were found to be impracticable because the basic health workers, with their multiple functions
    could do justice neither to malaria work nor to family planning work. The Mukherjee committee headed by the then Secretary of Health Shri Mukherjee, was appointed
    to review the performance in the area of family planning. The committee recommended separate staff for the family planning programme. The family planning
    assistants were to undertake family planning duties only. The basic health workers were to be utilised for purposes other than family planning. The committee
    also recommended to delink the malaria activities from family planning so that the latter would received undivided attention of its staff.
    5. MUKHERJEE COMMITTEE. 1966.
    Multiple activities of the mass programmes like family planning, small pox, leprosy, trachoma, NMEP (maintenance phase), etc. were making it difficult for the states
    to undertake these effectively because of shortage of funds. A committee of state health secretaries, headed by the Union Health Secretary, Shri Mukherjee, was set
    up to look into this problem. The committee worked out the details of the Basic Health Service which should be provided at the Block level, and some
    consequential strengthening required at higher levels of administration.
    6. JUNGALWALLA COMMITTEE, 1967.
    This committee, known as the “Committee on Integration of Health Services” was set up in 1964 under the chairmanship of Dr. N Jungalwalla, the then Director of
    National Institute of Health Administration and Education (currently NIHFW). It was asked to look into various problems related to integration of health services,
    abolition of private practice by doctors in government services, and the service conditions of Doctors. The committee defined “integrated health services” as :-

    a.
    A service with a unified approach for all problems instead of a segmented approach for different problems.
     
    b.
    Medical care and public health programmes should be put under charge of a single administrator at all levels of hierarchy.

    Following steps were recommended for the integration at all levels of health organisation in the country

    1Unified Cadre
      
    2Common Seniority
      
    3Recognition of extra qualifications
      
    4Equal pay for equal work
      
    5Special pay for special work
      
    6Abolition of private practice by government doctors
      
    7Improvement in their service conditions

    7. KARTAR SINGH COMMITTEE. 1973.
    This committee, headed by the Additional Secretary of Health and titled the "Committee on multipurpose workers under Health and Family Planning" was constituted to
    form a framework for integration of health and medical services at peripheral and supervisory levels. Its main recommendations were :-

    a. Various categories of peripheral workers should be amalgamated into a single cadre of multipurpose workers (male and female). The erstwhile auxiliary nurse
    midwives were to be converted into MPW(F) and the basic health workers, malaria surveillance workers etc. were to be converted to MPW(M). The work of 3-4 male
    and female MPWs was to be supervised by one health supervisor (male or female respectively). The existing lady health visitors were to be converted into female health supervisor.

    b One Primary Health Centre should cover a population of 50,000. It should be divided into 16 subcentres (one for 3000 to 3500 population) each to be staffed by a
    male and a female health worker.

    8. SHRIVASTAV COMMITTEE. 1975.
    This committee was set up in 1974 as "Group on Medical Education and Support Manpower" to determine steps needed to (i) reorient medical education in accordance
    with national needs & priorities and (ii) develop a curriculum for health assistants who were to function as a link between medical officers and MPWs. It recommended immediate action for :

    1. Creation of bonds of paraprofessional and semiprofessional health workers from within the community itself.

    2. Establishment of 3 cadres of health workers namely – multipurpose health workers and health assistants between the community level workers and doctors at PHC.

    3. Development of a “Refferal Services Complex”

    4. Establishment of a Medical and Health Education Commission for planning and implementing the reforms needed in health and medical education on the lines of
    University Grants Commission.

    Acceptance of the recommendations of the Shrivastava Committee in 1977 led to the launching of the Rural Health Service.
    9. BAJAJ COMMITTEE, 1986.
    An "Expert Committee for Health Manpower Planning, Production and Management" was constituted in 1985 under Dr. J.S. Bajaj, the then professor at AIIMS. Major recommendations are :-

    1.Formulation of National Medical & Health Education Policy.
      
    2.Formulation of National Health Manpower Policy.
      
    3.Establishment of an Educational Commission for Health Sciences (ECHS) on the lines of UGC.
      
    4.Establishment of Health Science Universities in various states and union territories.
      
    5.Establishment of health manpower cells at centre and in the states.
      
    6.
    Vocationalisation of education at 10+2 levels as regards health related fields with appropriate incentives, so that good quality paramedical personnel may be
    available in adequate numbers.
      
    7.Carrying out a realistic health manpower survey.

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    Nobel Prize in Physiology or Medicine 2011 and 2012

    Nobel Prize in Physiology or Medicine 2012

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